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Effects of Trace Elements and Mono- and Dithiols

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1978
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Toxicology and Applied Pharmacology
Volume 43, Issue 3, March 1978, Pages 439-448

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Effects of Trace Elements and Mono- and Dithiols on Mitochondrial Monoamine Oxidase of Rats

Nathaniel Revis and Carol Horton

University of Tennessee-Oak Ridge Graduate School of Biomedical Sciences and the Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830, USA

Received 26 May 1977; 

accepted 25 August 1977. 

Available online 3 October 2005.

The effects of several trace elements on mitochondrial monoamine oxidase (MAO) were studied. Elements were studied at a concentration of 1 mM; only mercury, cadmium, and copper were significantly effective in reducing the activity of this enzyme. Of several thiols tested, only dithiothreitol could reverse the inhibition of MAO by these elements. Evidence is also presented in this report to show that cysteine, homocysteine, and reduced glutathione inhibit this MAO, whereas dithiothreitol or dithioerythritol evoke stimulatory responses.
1By acceptance of this article, the publisher or recipient acknowledges the right of the U.S. Government to retain a nonexclusive, royalty-free license in and to any copyright covering the article.
2Research supported by the Energy Research and Development Administration under contract with Union Carbide Corporation.
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Toxicology and Applied Pharmacology
Volume 43, Issue 3, March 1978, Pages 439-448