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Dr. Nathaniel Revis

A Possible Mechanism for Cadmium

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1978
Nathaniel W. Revis, “A Possible Mechanism for Cadmium-Induced Hypertension in Rats”, Life Sciences, Volume 23 Issue 4, Pages 409-417, 1978

A Possible Mechanism for Cadmium-Induced Hypertension in Rats

Nathaniel Revis

The University of Tennessee-Oak Ridge Graduate School of Biomedical Sciences, and the Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830, USA

Revised 9 December 1977.
(With the technical assistance of Carol Horton)
Available online 16 November 2002.
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Bioavailability of Cadmium

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1984
Nathaniel W. Revis, “Bioavailability of Cadmium and its Human Consequence”, Technical Report DOE, DOE/ER/60094-T2, 1984

Bioavailability of Cadmium and its Human Consequence

N. W. Revis

Oak Ridge Research Inst., TN (USA). Research and Development Dept.

Subject
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CADMIUM; TOXICITY; DATA COMPILATION; DIET; DISEASES; DOSE-RESPONSE RELATIONSHIPS; HUMAN POPULATIONS; INTESTINAL ABSORPTION; KIDNEYS; TOBACCO SMOKES; ABSORPTION; AEROSOLS; BODY; COLLOIDS; DATA; DISPERSIONS; ELEMENTS; INFORMATION; METALS; NUMERICAL DATA; ORGANS; POPULATIONS; RESIDUES; SMOKES; SOLS; UPTAKE
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Degradation of perchloroethylene

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1987
Hadden, C. T., S. B. Benson, and N. W. Revis 1987. "Degradation of perchloroethylene and trichioroethylene by an environmentally isolated Bacillus".  Am. Soc. Microbiol.
 

Dietary Protein Effects on Cadmium and Metallothionein

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1984
Nathaniel W. Revis and Tanya R. Osborne, “Dietary Protein Effects on Cadmium and Metallothionein Accumulation in the Liver and Kidney of Rats”, Environmental Health Perspectives, Volume 54, Pages 83–91, 1984

Dietary Protein Effects on Cadmium and Metallothionein Accumulation in the Liver and Kidney of Rats

by Nathaniel W. Revis* and Tanya R. Osborne*

*Oak Ridge Research Institure, Oak Ridge, TN  37830

The relationship of dietary protein to cadmium absorption and tissue deposition was studied in male Sprague-Dawley rats exposed to different levels of cadmium in the drinking water. In animals fed a high-protein or low-protein diet and drinking water containing 25 or 50 ppm cadmium, liver and kidney cadmium and metaliothionein were both significantly higher in rats fed the high-protein diet for 2 to 4 months. These differences may possibly be explained by the concentration of cysteine observed between these two diets.
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Effect of Drinking Water Containing Chlorine on Cholesterol Metabolism

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1986
Revis, N.W., Osborne, T.R., McCauley, P., Bull, R., and Holdsworth, G.  "The Effect of Drinking Water Containing Chlorine on Cholesterol Metabolism in the White Carneau Pigeon and New Zealand Rabbit," Env. Res. (in press).
 

Effects of Trace Elements and Mono- and Dithiols

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1978
Abstract - selected


Toxicology and Applied Pharmacology
Volume 43, Issue 3, March 1978, Pages 439-448

________________________________________

Effects of Trace Elements and Mono- and Dithiols on Mitochondrial Monoamine Oxidase of Rats

Nathaniel Revis and Carol Horton

University of Tennessee-Oak Ridge Graduate School of Biomedical Sciences and the Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830, USA

Received 26 May 1977; 

accepted 25 August 1977. 

Available online 3 October 2005.

The effects of several trace elements on mitochondrial monoamine oxidase (MAO) were studied. Elements were studied at a concentration of 1 mM; only mercury, cadmium, and copper were significantly effective in reducing the activity of this enzyme. Of several thiols tested, only dithiothreitol could reverse the inhibition of MAO by these elements. Evidence is also presented in this report to show that cysteine, homocysteine, and reduced glutathione inhibit this MAO, whereas dithiothreitol or dithioerythritol evoke stimulatory responses.
1By acceptance of this article, the publisher or recipient acknowledges the right of the U.S. Government to retain a nonexclusive, royalty-free license in and to any copyright covering the article.
2Research supported by the Energy Research and Development Administration under contract with Union Carbide Corporation.
________________________________________
Toxicology and Applied Pharmacology
Volume 43, Issue 3, March 1978, Pages 439-448
      


 

Health Research Needed to Resolve

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1986
Nathaniel W. Revis, “Health Research Needed to Resolve Scientific Issues Surrounding Drinking Water Disinfection”, Environmental Health Perspectives, Volume 69, Pages 285-286, 1986

Health Research Needed to Resolve Scientific Issues Surrounding Drinking Water Disinfection



 

Lactate Dehydrogenase Isoenzymes

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1977

Nathaniel W. Revis, R. Y. Thomson and A. J. V. Cameron, “Lactate Dehydrogenase Isoenzymes in the Human Hypertrophic Heart”,  Cardiovascular Research, Volume 11 Issue 2, Pages 172-176, 1977

 

Lactate Dehydrogenase Isoenzymes in the Human Hypertrophic Heart

1. N. W. REVIS1,
2. R. Y. THOMSON and
3. A. J. V. CAMERON
+ Author Affiliations

1 Address for correspondence and reprints: N. W. Revis, University of Tennessee Biomedical
Graduate School, Biology Division, PO Box Y, Oak Ridge, Tennessee 37830, USA.

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Mercury in Soil

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1990
Nathaniel W. Revis, Tanya R. Osborne, G. Holdsworth and C. Hadden, “Mercury in Soil:  A Method for Assessing Acceptable Limits”, Environmental Contamination and Toxicology, Volume 19, Pages 221-226, 1990

HERO ID
196825
Reference Type                          
Research Article
Author(s) Revis NW; Osborne TR; Holdsworth G; Hadden C
Year 1990
Title Mercury in Soil: A Method for Assessing Acceptable Limits
Journal Archives of Environmental Contamination and Toxicology
Volume 19
Issue 2
Page(s)
221-226
Abstract Acceptable limits for mercury in soil were determined at a site with mercury contamination after measuring the soil concentration of total mercury, the species of mercury, and the intestinal absorption of mercuric sulfide by mice. The total concentration of mercury at this site ranged from 0.5 to 3,000 ppm. Of the total mercury present, 88% was identified as mercuric sulfide, 0.01% as methyl mercury, and 7% as elemental mercury. Intestinal absorption studies in mice following the intubation of203mercuric sulfide showed that 0.4% of the intubated dose was absorbed. We estimated an acceptable limit for mercury in soil at this site based on results of this study, on reports in the literature on the intestinal and pulmonary absorption of mercury species from air, water and food; and on the normal intake of total mercury in humans reported by the World Health Organization. Based on reports in the literature and results from the present studies, we suggest an acceptable limit for mercury in soil (at this site) to be 722 ppm. With a safety factor of 10 this limit would be reduced to 72 ppm.

 


 

Publication and Characterization of Plasma Membranes

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1975

John P. Durham, Norbel Galanti, Nathaniel W. Revis, "The Publication and Characterization of Plasma Membranes and the Subcellular Distribution of Adenylate Cyclase in Mouse Perotid Gland," Biochemica et Biophysica Acta, Volume 394 Issue 3, Pages 388 405, 1975

 

Relationship between Fibrosis and Lactate

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1978
Nathaniel W. Revis and A. J. V. Cameron, “The Relationship between Fibrosis and Lactate Dehydrogenase Isoenzymes in the Experimental Hypertrophic Heart of Rabbits”, European Society of Cardiology, 1978


The Relationship between Fibrosis and Lactate Dehydrogenase Isoenzymes in the Experimental Hypertrophic Heart of Rabbits

N. W. REVIS,1 and A. J. V. CAMERON

1 From the University of Tennessee—Oak Ridge Graduate School of Biomedical Sciences and the Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee2, and Department of Cardiology, University of Glasgow

Reprint requests to: Dr N. W. Revis, Biology Division, Oak Ridge National Laboratory, Post Office Box Y, Oak Ridge, Tennessee 37830, USA.

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Relationship of Dietary Iodide and Drinking Water

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1986
Nathaniel W. Revis, Paul McCauley and G. Holdsworth, “Relationship of Dietary Iodide and Drinking Water Disinfectants to Thyroid Function in Experimental Animals”, Environmental Health Perspectives, Volume 69, Pages 243-248, 1986



Relationship of Dietary Iodide and Drinking Water Disinfectants to Thyroid Function in Experimental Animals

N W Revis, P McCauley, and G Holdsworth

This article has been cited by other articles in PMC.

Abstract

The importance of dietary iodide on the reported hypothyroid effect of drinking water disinfectants on thyroid function was investigated. Previous studies have also showed differences in the relative sensitivity of pigeons and rabbits to chlorinated water.
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Relationship of Minerals Commonly Found

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1982
Revis, N.W., Schmoyer, R.L., and Bull, R.  "The Relationship of Minerals Commonly Found in Drinking Water to Atherosclerosis and Hypertension in Pigeons," J. AWWA 74:(12)656 659, 1982.
 

Sequestration of 45Ca2+

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1979
Nathaniel W. Revis and Nives Marusic, “Sequestration of 45Ca2+ by Mitochondria from Rabbit Heart, Liver and Kidney after Doxorubicin or Digoxin/Doxorubicin Treatment”, Experimental and Molecular Pathology, Volume 31, Issue 3, Pages 440-451, 1979


Sequestration of 45Ca2+ by Mitochondria from Rabbit Heart, Liver and Kidney after Doxorubicin or Digoxin/Doxorubicin Treatment



Nathaniel Revisa and Nives Marusica

aThe University of Tennessee-Oak Ridge Graduate School of Biomedical Sciences, and the Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830 USA

Received 30 April 1979
Revised 24 July 1979
Available online 29 April 2004

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The Relationship of Trace Elements (Lead and Cadmium) from Drinking Water to Atherosclerosis in the Pigeon

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1980
Revis, N.W.  "The Relationship of Trace Elements (Lead and Cadmium) from Drinking Water to Atherosclerosis in the Pigeon," J. Path. Enviro. Tox. 42:293 304, 1980.


 

Atherosclerosis and hypertension

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1981

Nathaniel W. Revis, Alan R. Zinsmeister and Richard Bull, “Atherosclerosis and Hypertension Induction by Lead and Cadmium Ions: An Effect Prevented by Calcium Ion”, Proceedings of the National Academy of Sciences U S A, Volume 78 Issue 10, Pages 6494–6498, 1981



Atherosclerosis and hypertension induction by lead and cadmium ions: an effect prevented by calcium ion.

N W Revis, A R Zinsmeister, and R Bull

This article has been cited by other articles in PMC.

Abstract

In epidemiological studies, both positive and negative correlations have been found between cardiovascular disease and mortality and the presence of several inorganic ions in the drinking water.

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Bioavailability of Cadmium and its Human Consequence

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1984
Bibliographic Citation
     
Document 
For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field.
For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability.
Title Bioavailability of Cadmium and its Human Consequence
Creator/Author Revis, N. W.
Publication Date 1984 Jan 01
OSTI Identifier OSTI ID: 6748022; Legacy ID: DE84014378
Report Number(s) DOE/ER/60094-T2
DOE Contract Number AC05-82ER60094
Other Number(s) Other: ON: DE84014378
Resource Type
Technical Report
Resource Relation Other Information: Paper copy only, copy does not permit microfiche production
Research Org Oak Ridge Research Inst., TN (USA). Research and Development Dept.
Subject 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CADMIUM; TOXICITY; DATA COMPILATION; DIET; DISEASES; DOSE-RESPONSE RELATIONSHIPS; HUMAN POPULATIONS; INTESTINAL ABSORPTION; KIDNEYS; TOBACCO SMOKES; ABSORPTION; AEROSOLS; BODY; COLLOIDS; DATA; DISPERSIONS; ELEMENTS; INFORMATION; METALS; NUMERICAL DATA; ORGANS; POPULATIONS; RESIDUES; SMOKES; SOLS; UPTAKE
Description/Abstract    Cadmium intake for the average adult in the USA from water, air and food is approximately 43 ..mu..g/day. This value does not include intake from cigarette smoking or industrial exposure. Intake from these sources would add significantly the total Cd body burden because, Cd absorption via the respiratory track is approximately 10 times the value observed for the gastrointestinal tract. Renal tubular damage is the only human disease in which a dose-response has been established for Cd intake. For renal tubular damage an intake of 200 to 440 ..mu..g/day for 50 years would be necessary to induce this disease in 50% of the exposed population. Thus a safety margin of 10 exists between present intake levels and the amount required to induce renal tubular damage. If animal studies, which show the induction of hypertension following the long-term exposure to drinking water containing 100 ppB Cd, were related to present human intake values of 43 ..mu..g/day the safety margin level would be considerably lower than 10. In contrast, to relate the data from animal studies on cadmium-induced tumors to present human intake values suggest a safety margin greater than 10. 59 references, 4 tables.
Country of Publication
United States
Language English
Format Medium: X; Size: Pages: 21
Availability
NTIS, PC A02; 3.
System Entry Date 2008 Feb 08

 

Dietary Protein Effects

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1984
Nathaniel W. Revis and Tanya R. Osborne, “Dietary Protein Effects on Cadmium and Metallothionein Accumulation in the Liver and Kidney of Rats”, Environmental Health Perspectives, Volume 54, Pages 83–91, 1984


Dietary Protein Effects on Cadmium and Metallothionein Accumulation in the Liver and Kidney of Rats

by Nathaniel W. Revis* and Tanya R. Osborne*

The relationship of dietary protein to cadmium absorption and tissue deposition was studied in male Sprague-Dawley rats exposed to different levels of cadmium in the drinking water. In animals fed a high-protein or low-protein diet and drinking water containing 25 or 50 ppm cadmium, liver and kidney cadmium and metaliothionein were both significantly higher in rats fed the high-protein diet for 2 to 4 months. These differences may possibly be explained by the concentration of cysteine observed between these two diets.
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Effect of Chlorinated Drinking Water on Myocardial Structure and Functions in Pigeons and Rabbits

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1985
Revis, N.W., Osborne, T.R., and Holdsworth, G.  "Effect of  Chlorinated Drinking Water on Myocardial Structure and Functions in Pigeons and Rabbits," 5th Conf. on Water Chlorination. Eds R. J. Jolly et al. 1985  page 365-373
 


 

Effectiveness of Chemical Carinogens

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1984
Nathaniel W. Revis, R. Bull, D. Laurie and C. A. Schiller, “The Effectiveness of Chemical Carinogens to Induce Atherosclerosis in the White Carneau Pigeon”, Toxicology, Volume 32, Issue 3, Pages 215-227, 1984


The Effectiveness of Chemical Carinogens to Induce Atherosclerosis in the White Carneau Pigeon


NW Revis, R Bull, D Laurie, CA Schiller

Abstract

The frequency of atherosclerotic lesions of the abdominal aorta has been reported to increase significantly in chickens exposed to benzo[a]pyrene and 7,12-dimethylbenz[a,h]anthracene. The present studies were performed to determine in another experimental model frequently used in atherosclerotic studies (i.e. White Carneau Pigeons) whether these and other chemical carcinogens enhance atherosclerosis.
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Glutathione Peroxidase Activity

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1978
Nathaniel W. Revis and Nives Marusic, “Glutathione Peroxidase Activity and Selenium Concentration in the Hearts of Doxorubicin-Treated Rabbits”, Journal of Molecular and Cellular Cardiology, Volume 10, Issue 10, Pages, 945-948, 1978


Glutathione Peroxidase Activity and Selenium Concentration in the Hearts of Doxorubicin-Treated Rabbits

N. W. Revis a, b and Nives Marusicb,a

aUniversity of Tennessee—Oak Ridge Graduate School of Biomedical Sciences, Oak Ridge, Tennessee 37830, U.S.A.

bBiology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830, U.S.A.

Received 15 December 1977
Accepted 13 February 1978
Available online 4 February 2004
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In Situ Stabilization of Heavy Metals in Soil by Microbial Systems

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1987
In Situ Stabilization of Heavy Metals in Soil by Microbial Systems

Presented by:  H. M. Edenborn, Oak Ridge Research Institute

IN SITU STABILIZATION OF HEAVY METALS IN SOIL BY MICROBIAL SYSTEMS

N.W. Revis, G. Holdsworth, K.M. Edenborn, C. Hadden, J.L. Elmore, and A.A. King.

Oak Ridge Research Institute, Oak Ridge, TN

ABSTRACT

The Environmental Protection Agency has approved the concept that heavy metal immobilization in soil, sediment, and sludge is an acceptable form of remediation for hazardous waste sites. Many metal sulfides are highly insoluble in aqueous solution and thus would oe relatively immobile in soil and/or sludge. The feasibility of exploiting the activity of naturally—occurring sulfate—reducing bacteria in immobilizing toxic heavy metals as sulfides in soil was examined using the mercury-contaminated East Fork Poplar Creek flood plain as a model system. Laboratory studies indicated that mercury added to sul"fate-amended flood plain soils was immobilized rapidly due to enhanced sulfate reduction activity. However, long-term field studies showed that mercury mobility in the soil was extremely low. Further study of the chemical forms of mercury present in these soils using differential extraction procedures strongly suggested that much of the immobilized mercury was already present in the sulfide form. This implies that sulfate reduction activity has been instrumental in the immobilization of mercury in these flood plain soils. The enhancement of sulfate reduction activity in soils and sediments contaminated with mercury and other toxic heavy metals that form insoluble sulfides may be an effective treatment for the remediation of contaminated hazardous waste sites.


 

Localization of Adenylate Cyclase

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1979
Nathaniel W. Revis, “Localization of Adenylate Cyclase in Unfixed Sections of Cardiac Muscle”, Journal of Histochemistry & Cytochemistry, Volume 27, Issue 10, Pages 1322-1326, 1979
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Metabolism of Lipids

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1979
Nathaniel W. Revis and A. J. V. Cameron, “Metabolism of Lipids in Experimental Hypertrophic Hearts of Rabbits”, Metabolism, Volume 28, Issue 6, Pages 601-613, 1979


Metabolism of Lipids in Experimental Hypertrophic Hearts of Rabbits

N.W. Revis,a, b and A.J.V. Camerona,b

a University of Tennessee-Oak Ridge Graduate School of Biomedical Sciences, The Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tenn.USA

b Department of Cardiology, University of Glasgow, Glasgow, Scotland.

Received 12 June 1978 
Available online 10 May 2004

Abstract

Cardiac hypertrophy was induced in rabbits by subcutaneous injection of thyroxine or isoprenaline or by surgically constricting the abdominal aorta. Alterations in lipid metabolism were observed in these hypertrophic hearts.
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Quantitative Method for Determining the Concentration of Mercury(II) Sulphide in Soils and Sediments

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1989
Nathaniel W. Revis, Tanya R. Osborne, Dawn Sedgley and Adolf King, "Quantitative Method for Determining the Concentration of Mercury(II) Sulphide in Soils and Sediments", Analyst, 1989, 114, 823-825
 

Relationship of Blood Cadmium Level to Hypertension and Plasma Norepinephrine Level

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1981
Revis, N.W., and Zinsmeister, A.R.  "The Relationship of Blood Cadmium Level to Hypertension and Plasma Norepinephrine Level: A Romanian Study12 (41159)," Proc. Society for Exper. Bio. and Med. 167:254 260, 1981.
 

Relationship of Drinking Water Disinfectants to Plasma Cholesterol

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1986
Nathaniel W. Revis, Paul McCauley, R. Bull and G. Holdsworth, “Relationship of Drinking Water Disinfectants to Plasma Cholesterol and Thyroid Hormone Levels in Experimental Studies”, Proceedings of the National Academy of Sciences U S A, Volume 83, Issue 5, Pages 1485-1489, 1986


Relationship of Drinking Water Disinfectants to Plasma Cholesterol and Thyroid Hormone Levels in Experimental Studies

N W Revis, P McCauley, R Bull, and G Holdsworth

This article has been cited by other articles in PMC.

Abstract

The effects of drinking water containing 2 or 15 ppm chlorine (pH 6.5 and 8.5), chlorine dioxide, and monochloramine on thyroid function and plasma cholesterol were studied because previous investigators have reported cardiovascular abnormalities in experimental animals exposed to chlorinated water.
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Response of the Adrenergic System

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1983
Nathaniel W. Revis, T. C. Major and C. Y. Horton, “The Response of the Adrenergic System in the Cadmium-Induced Hypertensive Rat”, International Journal of Toxicology, Volume 2, Issue 2, Pages 165-174, 1983


The Response of the Adrenergic System in the Cadmium-Induced Hypertensive Rat

N. W. Revis1
T. C. Major1
C. Y. Horton1

1
Oak Ridge Research Institute 113 Union Valley Road Oak Ridge, TN 37830

Abstract

Previous investigators, using an in vitro system, have shown that cadmium inhibits neuronal uptake of norepinephrine (NE). The current studies were performed to determine if the adrenergic system is altered in the cadmium-induced hypertensive rat.
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The Relationship of Dietary Protein to Metallothionein and Cadmium Induced Renal Damage

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1981
Revis, N.W.  "The Relationship of Dietary Protein to Metallothionein and Cadmium Induced Renal Damage," Toxicology  20:323 333, 1981.